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Figure 1 First-line Treatment Abbreviations: B = bendamustine; C = cyclophosphamide; Cb = chlorambucil; CLL = chronic lymphocytic leukemia; F = fludarabine; Obi = obinutuzumab; Ofa = ofatumumab; R = rituximab. *More advanced age, risk for toxicity, renal impairment, or patient preference; ˆIn case of contraindication for ibrutinib, with Pneumocystic jiroveci pneumonia prophylaxis and cytomegalovirus monitoring; ˆˆIn case of contraindication for both ibrutinib and idelalisib; ∼Take into account decreased toxicity with R versus increased progression-free survival with obi. Figure 2 Second-line Treatment Abbreviations: B = bendamustine; C = cyclophosphamide; Cb = chlorambucil; CLL = chronic lymphocytic leukemia; F = fludarabine; Obi = obinutuzumab; Ofa = ofatumumab; R = rituximab. *Late relapse: > 24 to 36 months after FCR or BR or > 6 to 12 months after CB anti-CD20 antibody; ˆIn case of contraindication for ibrutinib, with Pneumocystic jiroveci pneumonia prophylaxis and cytomegalovirus monitoring; ∼Only if risk factors for non-relapse mortality (age, World Health Organization Performance Score, comorbidity, No 10/10 human leukocyte antigen-matched donor, female donor for male patients) are low.